Researchers at Brigham & Women’s Hospital have developed electrically activated gold nanoparticles that can bore holes into cells’ outer membranes and allow DNA, RNA and proteins to pass through carrying their cargo. The team’s work was published in Advanced Functional Materials.
The team tested its technique using a DNA vaccine against hepatitis C in a mice model. Over the course of 3 months, the researchers did not observe any signs of toxicity. The newly developed delivery method induced high levels of anti-hepatitis C virus antibodies and immune cells that secreted inflammatory hormones.
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